The growth process of hierarchical porous hydroxyapatite microspheres precipitated by propionamide and citrate through hydrothermal synthesis

摘要

Hydroxyapatite (HA) microspheres were hydrothermally synthesized by using propionamide (PA) and trisodium citrate (Cit). The capability of PA and Cit to control ions release in synthesis solution contributed to the formation of hierarchical porous structure. The effect of hydrothermal time was investigated to explore the formation mechanism of HA microspheres. The result demonstrated that the morphology of products transformed from microsheets to microspheres as reaction time increased. Combining with the theory of Ostwald ripening, it was proposed that earlandite nanosheets as primary building units were firstly formed from nucleation and then self-assembled into the final HA micro-spheres.