Influence of polydopamine/polylactic acid coating on mechanical properties and cell behavior of 3D-printed calcium silicate scaffolds

摘要

3D printed bioactive ceramic scaffolds have been proved to contribute to enhancing osteoinduction and osseointegration. However, the poor mechanical property limits the further application of the scaffolds in the clinic. Therefore, it is an urgent need to fabricate scaffolds with good biological and mechanical properties. In this study, polydopamine/polylactic acid coated calcium silicate scaffolds (PDA-PLA-CS) were prepared by a 3D printing technology and sequentially immersed methods. The PDA-PLA-CS scaffolds exhibited excellent hydrophilicity. Compared to uncoated scaffolds, the mechanical property of PDA-PLA-CS scaffolds was remarkably improved. More importantly, the PDA-PLA-CS scaffolds also exhibited a positive effect on cell spreading due to the existence of PDA on the surface. This study provides a potential alternative to generate 3D printed scaffolds with excellent biological and mechanical properties for treating bone defects in the future. (C) 2020 Elsevier B.V. All rights reserved.