A biomimetic nano-hydroxyapatite/chitosan/poly(methyl vinyl ether-alt-maleic anhydride) composite with excellent biocompatibility

摘要

Nano-hydroxyapatite/chitosan/poly(methyl vinyl ether-alt-maleic anhydride) (NHA/CS/P(MVE-alt-MA)) composite was formed through electrostatic interaction. The results of characterization indicated that the nano-hydroxyapatite (NHA) in the composites was uniformly distributed in the polymer matrices (chitosan/poly(methyl vinyl ether-alt-maleic anhydride) (CS/P(MVE-alt-MA)). With the increase of NHA content, the porosity and strength of the composites increase first and then decrease. The mechanical properties of composite were better than those of the three kinds of single component, the maximum compressive strength of composite was up to 8.48 MPa. Moreover, this composite showed excellent biocompatibility through SD rat bone marrow mesenchymal stem cells (SDBMSCs) culture. Therefore, this composite which combined the advantages of various materials exhibited good mechanical properties and biocompatibility, it was expected to be applied in bone tissue repair. (C) 2019 Published by Elsevier B.V.