CHITOSAN COMPOSITE CONTAINING HYDROPHOBIC GROUP USEFUL FOR PHARMACEUTICAL CARRIER FOR PROVIDING EXCELLENT BIOCOMPATIBILITY AND BIODEGRADABILITY AND PREPARATION THEREOF

摘要

PURPOSE: Provided is a chitosan composite containing a hydrophobic group, which can encapsulate various hydrophobic pharmaceuticals and therapeutic proteins to give excellent biocompatibility and biodegradability, and thus is useful for pharmaceutical carrier. CONSTITUTION: The chitosan composite containing a hydrophobic group forms a nanosized self-aggregate in aqueous solution. Particularly, an amino group of chitosan is coupled with a carboxyl group of hydrophobic bile acid to form a nanosized self-aggregate. The chitosan is selected from the group consisting of water soluble glycol chitosan, chitosan oligomer and 50%-acetylated chitosan. The hydrophobic bile acid is selected from the group consisting of cholic acid, chenodeoxycholic acid, deoxycholic acid, lithocholic acid, 7-oxo-lithocholic acid and 5-beta-cholanic acid.