Polyvinyl alcohol nanofiber based three phase wound dressings for sustained wound healing applications

摘要

Herein we present our research on a novel three phase antibacterial wound dressing prepared from carbon nanotubes, silver nanoparticles (AgNPs) and polyvinyl alcohol nanofibers. The AgNPs were generated on carbon nanotubes surfaces to synthesize carbon nanotubes-AgNP nanoparticles which were added into the polyvinyl alcohol nanofibers prior to electrospinning to prepare PVA/carbon nanotubes-AgNP composite nanofibers. All characterizations confirmed the three phase nanofiber architecture. Owing to growth of AgNPs on carbon nanotubes surfaces and embedding into PVA nanofibers the wound dressings are proposed for sustained and safer wound healing applications. The antibacterial test results confirmed excellent bactericidal and prolonged bacterial growth inhibition properties of the nanocomposites which suggest their suitability as sustained antibacterial wound dressing biomaterial. (C) 2019 Elsevier B.V. All rights reserved.