Biological-Activity Predictions and Hydrogen Bonding Analysis in Chalcones: A Review

摘要

The paper has been designed to make a comprehensive review of a particular series of organic molecular assembly in the form of compendium. An overview of general description of twenty-two chalcone derivatives has been given. The biological activity spectra of chalcone derivatives have been correlated on structure activity relationships base which provides the different P_a (possibility of activity) and P_i (possibility of inactivity) values. Expositions of the role of intermolecular interactions in the identified derivatives have been discussed with the standard distance and angle cut-off criteria criteria as proposed by Desiraju and Steiner (1999) in an International monogram on crystallography. Histogram chart has been drawn to show the relative frequency of-occurrence of intermolecular hydrogen bonds in chalcone derivatives. Distance-angle scatter plots for inter-molecular interactions are presented for a better understanding of the packing interactions which exist in chalcone derivatives.