Self-Assembly Pluronic and β-Cyclodextrin to Hollow Nanospheres for Enhanced Gene Delivery

Min-Min Fan; Xi Zhang; Jie Qin; Bang-Jing Li; Xun Sun; Sheng Zhang

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Self-Assembly Pluronic and β-Cyclodextrin to Hollow Nanospheres for Enhanced Gene Delivery

机译：自组装Pluronic和β-环糊精到空心纳米球，增强基因传递。

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This paper studies a kind of hollow nanospheres prepared by self-assembly β-cyclodextrins (β-CDs) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (pluronic F127) for gene delivery. It was found that this kind of hollow nanospheres enable load PEI10K/DNA and the resulting F127NH₂βCD/(PEI10K/DNA) with 0.08 µg/well DNA display equal or higher gene delivery capability compared to PEI10K/DNA with 1 µg/well DNA in the absence or presence of serum. The cytotoxicity of the nanospheres was over 100 times lower than that of PEI10K.

机译：本文研究了一种通过自组装β-环糊精（β-CDs）和聚（环氧乙烷）-聚（环氧丙烷）-聚（环氧乙烷）（pluronic F127）制备的中空纳米球，用于基因传递。结果发现，这种空心纳米球能够负载PEI10K / DNA，并且所得到的F127NH _{2 βCD/（PEI10K / DNA）的0.08μg/孔DNA与PEI10K /具有相同或更高的基因传递能力。在不存在或存在血清的情况下，DNA的DNA浓度为1µµg /孔。纳米球的细胞毒性比PEI10K低100倍以上。}

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来源
《Macromolecular Rapid Communications》 |2011年第19期|p.1533-1538|共6页
作者
Min-Min Fan; Xi Zhang; Jie Qin; Bang-Jing Li; Xun Sun; Sheng Zhang;
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作者单位

State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China;

State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China;

State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China;

Chengdu Institute of Biology, Chinese Academy of Science, Chengdu 610041, China;

West China School of Pharmacy, Sichuan University, Chengdu 610041, China;

State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China;

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正文语种 eng
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关键词
cyclodextrins; dendrimer; gene delivery; self-assembly; supramolecular hollow nanospheres;

机译：环糊精;树状大分子;基因传递;自组装;超分子空心纳米球;

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1. Self-assembly pluronic and β-cyclodextrin to hollow nanospheres for enhanced gene delivery [J] . Fan M.-M., Zhang X., Qin J., Macromolecular rapid communications: Publishing the newsletters of the European Polymer Federation . 2011,第19期

机译：自组装普朗尼克和β-环糊精到空心纳米球中以增强基因传递
2. Self-assembly of β-cyclodextrin and pluronic into hollow nanospheres in aqueous solution [J] . Qin J., Meng X., Li B., Journal of Colloid and Interface Science . 2010,第2期

机译：β-环糊精和普卢尼克在水溶液中的自组装成空心纳米球
3. Self-assembly of carboxymethyl konjac glucomannan-g-poly(ethylene glycol) and (α-cyclodextrin) to biocompatible hollow nanospheres for glucose oxidase encapsulation [J] . Quan Li, Bing Xia, Mickey Branham Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2011,第1期

机译：羧甲基魔芋葡甘露聚糖-g-聚（乙二醇）和（α-环糊精）自组装到生物相容性空心纳米球中进行葡萄糖氧化酶封装
4. SUPRAMOLECULAR ASSEMBLY OF CYCLODEXTRIN-BASED NANOSPHERES FOR GENE DELIVERY [C] . Min-min Fan, Xi-Zhang, Bang-jing Li, Symposium on innovative polymers for controlled delivery: Abstract book. . 2010

机译：基于环糊精的纳米球的超分子组装
5. Enhanced delivery of anti-retroviral agents to the CNS: Effect of pluronics. [D] . Shaik, Mohammed Muzakkir Naveed. 2008

机译：增强抗逆转录病毒药物向中枢神经系统的递送：普朗尼克斯的作用。
6. The proper strategy to compress and protect plasmid DNA in the Pluronic L64-electropulse system for enhanced intramuscular gene delivery [O] . Yutong He, Yili Liu, Zhe Sun, 2019

机译：在Pluronic L64电脉冲系统中压缩和保护质粒DNA以增强肌肉内基因传递的正确策略
7. Supramolecular assembly of cyclodextrin-based nanospheres for gene delivery [O] . Fan Min-min, Xi-Zhang, Li Bang-jing, 2011

机译：基于环糊精的纳米球的超分子组装

Self-Assembly Pluronic and β-Cyclodextrin to Hollow Nanospheres for Enhanced Gene Delivery

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