Early detection of deep vein thrombosis in patients with coronavirus disease 2019: who to screen and who not to with Doppler ultrasound?

摘要

Purpose Aim of the study is to evaluate the incidence of DVT in COVID-19 patients and its correlation with the severityof the disease and with clinical and laboratory findings.Methods 234 symptomatic patients with COVID-19, diagnosed according to the World Health Organization guidelines,were included in the study. The severity of the disease was classified as moderate, severe and critical. Doppler ultrasound(DUS) was performed in all patients. DUS findings, clinical, laboratory’s and therapeutic variables were investigated bycontingency tables, Pearson chi square test and by Student t test and Fisher’s exact test. ROC curve analysis was applied tostudy significant continuous variables.Results Overall incidence of DVT was 10.7% (25/234): 1.6% (1/60) among moderate cases, 13.8% (24/174) in severely andcritically ill patients. Prolonged bedrest and intensive care unit admission were significantly associated with the presence ofDVT (19.7%). Fraction of inspired oxygen, P/F ratio, respiratory rate, heparin administration, D-dimer, IL-6, ferritin andCRP showed correlation with DVT.Conclusion DUS may be considered a useful and valid tool for early identification of DVT. In less severely affected patients,DUS as screening of DVT might be unnecessary. High rate of DVT found in severe patients and its correlation with respiratoryparameters and some significant laboratory findings suggests that these can be used as a screening tool for patients whoshould be getting DUS.