Ru(Ⅱ)-Catalyzed Amination of Aryl Fluorides via η~6-Coordination

摘要

We developed a Ru/hemilabile-ligand-catalyzed nucleophilic aromatic substitution (S_NAr) of aryl fluorides as the limiting reagents. Significant ligand enhancement was demonstrated by the engagement of both electron-rich and neutral arenes in the S_NAr amination without using excess arenes. Preliminary mechanistic studies revealed that the nucleophilic substitution proceeds on a η~6 -complex of the Ru catalyst and the substrate, and the hemilabile ligand facilitates dissociation of products from the metal center.