Bioorganometallic Chemistry. 5. Molecular Recognition of Aromatic Amino Acid Guests by Cp~*Rh-Nucleobase/Nucleoside/Nucleotide Cyclic Trimer Hosts in Aqueous Solution

摘要

The molecular recognition of aromatic amino acids with bioorganometallic hosts 1—4 in aqueous solution, as studied by ~1H NMR and NOE techniques, occurs predominately via a π—π interaction, and, in the case of L-Trp, additional electronic/hydrophobic interactions with hosts are possible. Further molecular modeling studies and NMR experiments with other potential biological guests are being explored to understand the scope of these host—guest interactions, all in aqueous solution.