Supraphos: A Supramolecular Strategy To Prepare Bidentate Ligands

摘要

Bidentate chelating ligands comprise an important class of compounds for the construction of transition metal catalysts. As compared to monodentate ligands, however, the synthesis is generally more complex and time-consuming. This is especially inconvenient for reactions that need intensive ligand-optimization. Methodologies that enable the synthesis of sufficiently large libraries of bidentate phosphorus containing ligands are scarce, and new strategies are required to prepare diverse catalyst libraries that can be used for high throughput experimentation. Here, we report a supramolecular strategy to make bidentate ligands that involves simple mixing of monomeric ligands. A small combinatorial library is used in the palladium-catalyzed allylic alkylation, yielding up to 97% ee.