Zirconium-Mediated S_N2' Substitution of Allylic Ethers:Regio- and Stereospecific Formation of Protected Allylic Amines

摘要

In the past 20 years,metal-promoted S_N2' reactions with carbon nucleophiles have become valuable tools in organic synthesis.In that period,several protocols for stoichiometric and catalytic copper-mediated allylic substitutions with carbon nucleophiles that allow complete control over regio- and stereoselectivity of the reactions have been developed.In comparison,S_N2' substitution reactions with heteroatom nucleophiles are virtually unexplored.