Total Synthesis of Piericidin A1 and B1

摘要

The piericidins are an important class of biologically active natural products isolated from Streptomyces mobaraensis and 5.pactam of which piericidin Al (1) is the prototypical member.Piericidin A1 is one of the most potent inhibitors of the mitochon-drial electron transport chain protein NADH-ubiquinone reductase (complex I,K_i=0.6-1.0 nM) defined to date and has contributed extensively to the elucidation of the enzyme properties.