Catalytic Ni/Cr-Mediated Macrocyclization without Use of High-Dilution Techniques

摘要

We recently reported that the rate of the catalytic Cr-mediated coupling reaction is dramatically accelerated in the presence of 3,3'-dimethyl-2,2'dipyridyl.This observation immediately suggests several new directions for expanding the scope of Cr-mediated coupling reactions.In this communication,we would like to report a successful extension of this observation to catalytic Ni/Cr-mediated macrocyclization without use of high-dilution techniques.