Computational Study of Phosphatase Activity in Soluble Epoxide Hydrolase:High Efficiency through a Water Bridge Mediated Proton Shuttle

摘要

Recently,a secondary enzymatic activity has been found in the N-terminal domain of the soluble epoxide hydrolase1(sEH),an essential ubiquitous enzyme involved in the process of detoxification in living cells.The localized high sEH's presence in mammalian livers,as well as in kidney and vascular tissues,makes sEH a promising target for hypertension and acute respiratory syndrome treatment.