Catalytic Enantioselective Negishi Reactions of Racemic Secondary Benzylic Halides

摘要

During the past two years,progress has been achieved in developing nickel-catalyzed cross-coupling reactions of secondary alkyl electrophiles.To fully exploit this family of carbon-carbon bond-forming processes,one must be able to accomplish them enantioselectively.We recently described the first examples of catalytic asymmetric cross-couplings of secondary electrophiles,employing alpha-bromoamides as substrates.