Lectin Arrays for Profiling Cell Surface Carbohydrate Expression

摘要

Cell surface carbohydrates play critical roles in many fundamental cellular processes,such as cell-cell communication,cell-extracellular matrix interactions,and immune response modulation.Different cell types vary in the nature of their surface carbohydrate expression,and a single cell type may change its surface carbohydrate expression profile during cell growth and differentiation processes.Altered carbohydrate expression patterns have also been observed on tumor cells,and may play a role in the escape of tumor cells from immune surveillance as well as metastasis.Effective tools for the identification of cell surface carbohydrate expression are essential to the study of these and other phenomena.