Organocatalytic Asymmetric Direct Alkylation of α-Diazoester via C-H Bond Cleavage

摘要

A new variant of phosphoric acid-catalyzed C—C bond forming reaction, direct alkylation of α-diazoester, via C—H bond cleavage was presented. The resulting products, β-amino-α-diazoesters, are highly functionalized and useful synthetic precursors for various types of β-amino acids. Further synthetically useful direct transformations promoted by chiral phosphoric acid catalysts are underway.