Total Synthesis of Salinosporamide A

摘要

Recently,Fenical and associates at the Scripps Institute of Oceanography reported on the cultivation and phylogenetic characterization of a new group of actinomycete bacteria,widely distributed in oceanic sediments.The term Salinospora was advanced to correlate the strains.Following preliminary screening,a highly active metabolite,termed salinosporamide A(1,Figure 1),was identified and isolated from these sediments.