Nickel-Catalyzed Intermolecular Alkyne Insertion into Cyclobutanones

摘要

Transition-metal-catalyzed or-mediated reactions involving carbon-carbon bond cleavage have gained significant attention because they provide new organic transformations that are otherwise difficult to achieve.For example,cleaving an unreactive carbon-carbon single bond by inserting an unsaturated organic functionality like a carbon-carbon triple bond into it would be a potentially useful protocol for constructing carbon frameworks.Such an insertion reaction is highly atom-economical,in contrast to cross-coupling reactions which produce significant amounts of undesirable metal salts(eq 1).