Cooperative Friedel-Crafts Catalysis in Heterobimetallic Regime:Alkylation of Aromatics by pi-Activated Alcohols

摘要

By virtue of its astonishing success with regard to versatility,scope,and applicability,Friedel-Crafts alkylation reaction (hereafter FCA) continues to attract synthetic chemists to further enrich a knowledge base of more than 125 years.The history of FCA catalysts witnessed many landmarks in both homogeneous and heterogeneous regimes.In the former case,transition metal halides are long established as FCA catalysts.On the contrary,catalysts bearing a high-valent Lewis acidic transition metal core,which are so well adapted for many organic reactions,remain very little explored toward FCA.