Reversible Insulin Self-Assembly under Carbohydrate Control

摘要

The biological properties of peptides and proteins are under significant influence by their molecular weights,which impact,among other things,diffusion rates and kidney-mediated clearances.The rate of diffusion,in turn,is proportional to the half-life of subcutaneously injected depots of peptide and protein drugs.Insulin provides a good illustration:Monomeric insulins are fast acting (t_(1/2) 1 h),and hexameric insulins are intermediary acting (t_(1/2) 2-4 h);on the other hand,insulins that bind to high molecular weight proteins or form soluble high molecular complexes are long acting (t_(1/2) > 10 h).