Highly Active,Regioselective,and Enantioselective Hydroformylation with Rh Catalysts Ligated by Bis-3,4-diazaphospholanes

摘要

As with catalytic hydrogenation of alkenes by rhodium complexes,key attributes of rhodium-catalyzed alkene hydroformyla-tion(perfect atom economy,inexpensive reactants,demonstrated performance on industrial scales,readily modified phosphorus ligands)make pursuit of the enantioselective transformation irresistible.Whereas hydrogenation effects net loss of the C=C functional group,hydroformylation results in its transformation to a more versatile functional group,the aldehyde.Although new ligand developments over the last fifteen years have yielded significant progress,the general application of enantioselective hydroformylation lags well behind that of enantioselective hydrogenation.