Design and Synthesis of Zinc-Selective Chelators for Extracellular Applications

摘要

Zinc (Zn~(2+)) is found in every cell in the human body and is mostly tightly bound to proteins as a key component of numerous enzymes and transcription factors. Chelatable Zn~(2+) co-localizes with glutamate in the synaptic vesicles of certain glutamatergic vesicles in the mammalian brain, including the hippocampus, amygdala, and neocortex.Free Zn~(2+) exists at a concentration of a few millimolar in the vesicles of presynaptic neurons and is released during synaptic activity or depolarization, modulating the function of certain ion channels and receptors.Many reports describe the significance of Zn~(2+) in biological systems, but its mechanisms of action are poorly understood.