Peptide Macrocyclization: The Reductase of the Nostocyclopeptide Synthetase Triggers the Self-Assembly of a Macrocyclic Imine

摘要

Nonribosomal peptides (NRPs) have attracted considerable attention from scientific and medical communities and gave rise to a wide assortment of therapeutic agents.Specifically,the biological activity of many of these complex natural products,including the immunosuppressant cyclosporin and the last resort antibiotic daptomycin,relies on the macrocyclization of their peptide backbone.