Helix Propensity of Highly Fluorinated Amino Acids

摘要

Highly fluorinated amino acids have been used to stabilize proteins for potential application in various protein-based biotechnologies,such as protein therapeutics,industrial scale biotransformations,and biosensors.To enhance protein stability,natural hydrocarbon amino acids have been substituted with highly fluorinated amino acids.The effect of enhanced protein stability upon replacing hydrocarbon residues with fluorocarbon residues is referred to as the fluoro-stabilization effect.