Control of Antigen Presentation with a Photoreleasable Agonist Peptide

摘要

T cells survey target cells by scanning for antigenic peptides presented by major histocompatibility complex molecules (pMHC) with T cell receptor (TCR).Engagement of pMHC by TCR induces a cascade of signaling events,including a rise in intracellular calcium levels and the formation of a large scale spatial pattern of signaling and adhesion molecules called the immunological synapse (IS).Recent studies suggest a direct role for the spatial pattern of molecules in the synapse with respect to regulation of TCR signaling.