Sequential Hydrocarbon Functionalization:Allylic C-H Oxidation/Vinylic C-H Arylation

摘要

Sequential C-H bond transformations have the potential to streamline the synthesis of small molecules by enabling the rapid buildup of molecular complexity from inert functionality with minimal functional group manipulations.Herein we report a one-pot Pd(II)/sulfoxide-catalyzed allylic C-H oxidation/vinylic C-H arylation of alpha-olefins to furnish E-arylated allylic esters with high regio- and stereoselectivities (eq 1).