Antimicrobial Leucocin Analogues with a Disulfide Bridge Replaced by a Carbocycle or by Noncovalent Interactions of Allyl Glycine Residues

摘要

Type IIa bacteriocins are antimicrobial peptides from lactic acid bacteria that are useful for food preservation because of their nanomolar activity against pathogens such as Listeria monocytogenes.They are ribosomally synthesized and have a characteristic YGNGV sequence near the N-terminus as well as a conserved disulfide bond.Leucocin A(LeuA,37 residues)(1)from Leu-conostoc gelidum was the first type IIa bacteriocin whose sequence was reported(Figure 1),but more than 25 of such"pediocin class"of peptides are now known.