Stabilization of NH Tautomers of Quinolines by Osmium and Ruthenium

摘要

Intramolecular transfer of a proton in tautomeric systems is the key step in numerous important biological processes.It is not always clear which tautomeric form is responsible for the biological activity.For many biological transformations,the energetically less stable tautomer is often an active intermediate,which dictates the mechanism and the formed product.Noncovalent H-bonding interactions are also responsible for the stability of some tautomers.