Tris(trimethylsilyl)silyl-Governed Aldehyde Cross-Aldol Cascade Reaction

摘要

Polyketides constitute a large class of natural products,and approximately 1% exhibit biological activity,which is 5 times higher than the average in natural products.beta-Hydroxy carbonyls and/or 1,3-diols are a common motif in this class of biologically important compounds,and the aldol reaction has emerged as a recurrent method for formation of these substructures.Numerous aldol methods utilize ester-,thioester-,or ketone-enolates as the nucleophile to circumvent problems associated with the aldehyde cross-aldol products.