Enantioselective Reductive Coupling of Acetylene to N-Arylsulfonyl Imines via Rhodium Catalyzed C-C Bond-Forming Hydrogenation: (Z)-Dienyl Allylic Amines

摘要

We report the first highly enantioselective catalytic vinylation of aldimines. The present protocol does not employ preformed organometallic reagents nor does it generate stoichiometric byproducts. Reductions employing hydrogen as terminal reductant, termed "hydrogenations," are used extensively in academia and industry. As further demonstrated by the results herein, C-C bond formations employing hydrogen as terminal reductant, termed "C-C bond forming hydrogenations," evoke boundless possibilities in terms of innovative methodologies and applications to arise in the future.