Chemical Modification of Monolayer-Protected Gold Nanoparticles Using Hyperbaric Conditions

摘要

We demonstrate that hyperbaric pressure conditions can be used to facilitate interfacial Diels-Alder reactions in gold MPN environments that do not proceed efficiently at ambient pressure. Because the dramatic reaction acceleration using high pressure is unprecedented on metal nanoparticle surfaces the results suggest that hyperbaric conditions can be used to facilitate other reactions subject to hyperbaric acceleration (or retardation) in the MPN environment and be exploited to covalently link carbohydrates, proteins, nucleic acids, and other biomolecules using a Diels-Alder cycloaddition reaction. We are currently pursuing these ideas.