Total Synthesis of Plusbacin A_3: A Depsipeptide Antibiotic Active Against Vancomycin-Resistant Bacteria

摘要

We have described the first total synthesis of plusbacin A_3, a promising depsipeptide antibiotic activity against vancomycin-resistant organisms. Future studies are aimed at the study of the structure and function of this very promising antibacterial agent. The results of these studies will be reported in due course.