Intermolecular, Catalytic Asymmetric Hydroamination of Bicyclic Alkenes and Dienes in High Yield and Enantioselectivity

摘要

Asymmetric hydroamination of olefins would be an efficient means to access chiral, nonracemic alkylamines, and development of stereoselective catalysts for these processes has been a longstanding challenge. Only recently have intramolecular, catalytic hydroaminations of alkenes and allenes been reported with a high level of enantioselection. However, no example of intermolecularrnhydroamination of alkenes has been reported with both high yield and high enantioselectivity.