Steric Tuning of Silylacetylenes and Chiral Phosphine Ligands for Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of Enones

摘要

Rhodium-catalyzed asymmetric conjugate addition to α,β-unsaturated ketones and related compounds is now well-recognized to be one of the most efficient methods of introducing aryl and alkenyl groups with high enantioselectivity. On the other hand, asymmetric conjugate addition of alkynyl groups has not been well-developed in spite of its high synthetic utility.