Biomimetic Total Synthesis of (-)-Erinacine E

摘要

In 1996, (-)-erinacine E (1) (Figure 1) was reported to be a strong stimulator of nerve growth factor (NGF) synthesis from the mycelia of Hericium erinaceum whose fruiting bodies have been known as Chinese medicine or food. Two years later, a Pfizer research group isolated 1 from a different source, the fermentation broth of Hericium ramosum CL24240, and disclosed that 1 was a potent, highly selective κ-opioid receptor agonist.