Seeing through Macromolecules: T_2-Filtered NMR for the Purity Assay of Functionalized Nanosystems and the Screening of Biofluids

摘要

Once established as the standard technique for the determination of organic structures, NMR has rapidly evolved into one of the most powerful tools for investigating different properties of molecules and materials. High resolutions achieved nowadays ultimately have made it possible to obtain quality spectra even on complex matrices or crude mixtures, which often provide an overwhelming amount of information. For this reason, much effort in modern NMR spectroscopy has been devoted to the simplification of crowded spectra that invariably result from complex systems. Ranging from multiplicity editing to signal suppression and selective filtration, this area of research has generated such sophisticated techniques that a proper "spectral editing" is often preferable to more time-consuming preprocessing of the sample.