Palladium-Catalyzed Alkenylation of Quinoline-N-oxides via C-H Activation under External-Oxidant-Free Conditions

摘要

Selective activation of C-H bonds catalyzed by transition metals can assemble value-added molecules through C-C bond formation. This synthetic strategy is intriguing for the chemical and pharmaceutical industries because it may not only significantly simplify and shorten the synthetic route for various types of organic compounds but also allow the utilization of readily available, cheap, and environmentally benign starting materials. Recently, there has been much progress in terms of synthesis efficiency and atom economy in direct C-C bond formation by aromatic compounds catalyzed by transition metals via activation of a normally unreactive C-H bond.