Direct Asymmetric Reductive Amination

摘要

β-Amino acid derivatives are valuable chiral building blocks in the synthesis of Pharmaceuticals.' Asymmetric hydrogenation of protected dehydroamino acid derivatives such as N-acyl enamines, along with other methods for chiral amine synthesis, has proven to be a valuable methodology for the preparation of these targets. However, from an efficiency standpoint, all of these methods require additional steps involving manipulation of the N-protecting group.