TBDPS and Br-TBDPS Protecting Groups as Efficient Aryl Group Donors in Pd-Catalyzed Arylation of Phenols and Anilines

摘要

Aryl-aryl bond formation is an important process because of the unique pharmaceutical features and wide applications of biaryls in material science. Traditionally, aryl-aryl bonds are made via cross-coupling reactions between aryl halide (or equivalent) and arylmetal components. Recently, a number of excellent transition-metal-catalyzed direct C-H arylation methodologies have emerged. However, these methods are not without boundaries. Thus, intermolecular versions often suffer from low reactivity and/ or regioselectivity, which in some cases can be circumvented by the introduction of a directing group,~(3k) including a removable directing group.