An efficient protocol for the synthesis of monofluoroalkylated (hetero) arenes via Pd-catalyzed alpha-(hetero)arylation of alpha-fluoroketones with (hetero)aryl bromides

摘要

An efficient synthesis of monofluoroalkylated N-heteroarenes using alpha-fluoroketones as monofluoroalkyl reagents was developed. A variety of novel alpha-(hetero)aryl-alpha-fluoroketones and monofluoroalkylated N-heteroarenes were obtained in moderate to good yields. Notable advantages of this protocol include a low catalyst loading, easily prepared monofluoroalkyl reagents and wide substrate scope. (C) 2020 Published by Elsevier Ltd.