Thiolate S-Oxygenation Controls Nitric Oxide (NO) Photolability of a Synthetic Iron Nitrile Hydratase (Fe-NHase) Model Derived from Mixed Carboxamide/Thiolate Ligand

摘要

Nitrile hydratase (NHase) is an iron- or cobalt-containing enzyme that catalyzes the hydrolysis of nitriles (R-C≡N) to the corresponding amides [R-(C=O)-NH_2]. It contains a non-heme Fe(III) or non-corrinoid Co(III) center bound to a unique array of ligands at the active site. The crystal structure of iron NHase (Fe-NHase) revealed an Fe(III) center in an octahedral geometry.