Photoinduced Intracellular Controlled Release Drug Delivery In Human Cells By Gold-capped Mesoporous Silica Nanosphere

摘要

Recent developments in designing surface functionalized mesoporous silica nanospheres (MSNs) have revealed the promising potential of utilizing these structurally ordered materials for drug/ gene delivery. For many practical drug delivery applications, such as chemotherapy, "zero-premature release" and "stimuli-responsive controlled release" of the precious and often toxic pharmaceutical cargo are two important prerequisites that would impact the therapeutic efficacy and cytotoxicity of drug delivery. Unfortunately, constructing drug delivery carriers with control over the location and timing of drug release under physiological conditions remains a challenge.