Total Synthesis Of The Lycopodium Alkaloid (+)-serratezomine A

摘要

The Lycopodium alkaloids have provided some of the most intricately structured and stereochemically dense specimens among naturally occurring small molecules. The attendant challenge for chemical synthesis, often combined with their promise as potential therapeutics, has led to broad interest in their total chemical synthesis. Recent reports have detailed rather concise preparations of (-)-fawcettimine, (+)-fawcettidine, (-)-lycopodine, lyconadin A and B, and (-)-cernuine. Importantly, valuable new chemical methods have been developed in nearly every case to solve specific synthetic challenges while also avoiding synthetic routes that would not address the important issue of supply.