Asymmetric Total Synthesis, Stereochemical Stability and Cancer Cell Killing Effects of Stemona Alkaloids

摘要

Stemonamine (1) and isostemonamine (2), both of which were isolated from Stemona japonica Mq., have attractive structural features such as consecutive spiro quaternary centers and fused four ring systems. These alkaloids are a pair of diastereomers bearing different stereochemistry at C-12 position, and were isolated as racemic form. Therefore, it was anticipated that they have racemic and epimeric pathway from the one to the others. In this research, asymmetric total synthesis of stemonamine and isostemonamine was achieved, and their optical stability and cancer cell killing effects were also firstly revealed.