Gold-Catalyzed Three-Component Tandem Process: An Efficient and Facile Assembly of Complex Butenolides from Alkynes, Amines, and Glyoxylic Acid

摘要

Butenolides are prevalent structural motifs in more than 13 000 natural products, some acting as antibiotic, antifungal, antifouling, or anticancer agents as well as Pharmaceuticals such as Merck's Rofecoxib. General and convenient methods for construction of butenolide skeletons bearing multiple reactive sites for further func-tionalizations are of great interest. Herein, we report an expeditious and practical gold-catalyzed multicomponent reaction (MCR) for the formation of polysubstituted butenolides in a tandem manner.