Fibrillar vs Crystalline Full-Length β-2-Microglobulin Studied by High-Resolution Solid-State NMR Spectroscopy

摘要

Elucidating the fine structure of amyloid fibrils as well as understanding their processes of nucleation and growth remains a crucial challenge, linked to our current poor insight into protein misfolding and aggregation diseases such as Alzheimer's and Parkinson's. Since the details of fibril architecture are only just beginning to be understood, obtaining atomic-scale structural information on amyloid fibrils is an essential priority to understand their supramolecular structure and shed light on the processes of fibrillation.