首页> 外文期刊>Journal of the American Chemical Society >Diastereo- and Enantioselective Conjugate Addition of a-Ketoesters to Nitroalkenes Catalyzed by a Chiral Ni(OAc)_2 Complex under Mild Conditions
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Diastereo- and Enantioselective Conjugate Addition of a-Ketoesters to Nitroalkenes Catalyzed by a Chiral Ni(OAc)_2 Complex under Mild Conditions

机译:手性Ni(OAc)_2配合物在温和条件下催化α-酮酸酯的非对映体和对映体选择性共轭加成至硝基烯烃

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摘要

Because of the high potential to rapidly increase molecular complexity as well as the rich chemistry of the nitro group, catalytic diastereo- and enantioselective conjugate addition of carbon pro-nucleophiles to nitroalkenes has attracted much attention. While pyruvic acid, a representative 1,2-dicarbonyl compound, is an important C2 and C3 donor unit in biosynthesis, related a-ketoesters have rarely been used as nucleophiles in asymmetric catalysis.
机译:由于具有迅速增加分子复杂性的高潜力以及硝基的丰富化学性质,碳亲核体向硝基烯烃的催化非对映和对映选择性共轭加成反应引起了人们的广泛关注。尽管丙酮酸是一种代表性的1,2-二羰基化合物,是生物合成中重要的C2和C3供体单元,但相关的α-酮酸酯很少用作不对称催化中的亲核试剂。

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  • 来源
    《Journal of the American Chemical Society》 |2010年第12期|p.4036-4037|共2页
  • 作者单位

    RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanrnGraduate School of Science and Engineering, Saitama University, 255 Shimo-okubo, Sakura-ku, Saitama 338-8570, JapanrnExploratory Research Laboratories, Kyorin Pharmaceutical Co., Ltd., 2399-1, Nogi, Nogi-Machi, Shimotsuga-Gun, Tochigi 329-0114, Japan;

    rnRIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;

    rnAdvanced Technology Support Division, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;

    rnRIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;

    RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;

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