Iridium-Catalyzed α-Alkylation of Acetates with Primary Alcohols and Diols

摘要

Carboxylic acids and their esters are among the most frequently used compounds in organic chemistry and are widely used as raw materials in the organic and industrial chemistry fields. In general, carboxylates are prepared by coupling of ester enolate anions with alkyl halides and tosylates or the reaction of silyl ketene acetals with alkyl halides in the presence of a Lewis acid. However, the main disadvantages of these methodologies are the formation of lithium salts and undesired side products.